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Acknowledgements This work was supported by the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre

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281 In the rat, The KD exacerbated disorders of glucose and lipid metabolisms and activated the renin-angiotensin-aldosterone system, 279 and the ketone body might reduce eNOS expression via NF-B singling pathway in vein endothelial cells, 280 which could collectively contribute to hypertension and endothelial dysfunction

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